Radiosynthesis and Biodistribution of 18F-Linezolid in Mycobacterium tuberculosis-Infected Mice Using Positron Emission Tomography
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چکیده
منابع مشابه
The biodistribution of 5-[18F]fluoropyrazinamide in Mycobacterium tuberculosis-infected mice determined by positron emission tomography
5-[18F]F-pyrazinamide (5-[18F]F-PZA), a radiotracer analog of the first-line tuberculosis drug pyrazinamide (PZA), was employed to determine the biodistribution of PZA using PET imaging and ex vivo analysis. 5-[18F]F-PZA was synthesized in 60 min using a halide exchange reaction. The overall decay-corrected yield of the reaction was 25% and average specific activity was 2.6 × 106 kBq (70 mCi)/μ...
متن کاملNoninvasive determination of 2-[18F]-fluoroisonicotinic acid hydrazide pharmacokinetics by positron emission tomography in Mycobacterium tuberculosis-infected mice.
Tuberculosis (TB) is a global pandemic requiring sustained therapy to facilitate curing and to prevent the emergence of drug resistance. There are few adequate tools to evaluate drug dynamics within infected tissues in vivo. In this report, we evaluated a fluorinated analog of isoniazid (INH), 2-[(18)F]fluoroisonicotinic acid hydrazide (2-[(18)F]-INH), as a probe for imaging Mycobacterium tuber...
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E. A. Weinstein, L. Liu, A. A. Ordonez, H. Wang, J. M. Hooker, P. J. Tonge, and S. K. Jain Center for Infection and Inflammation Imaging, Center for Tuberculosis Research, Department of Medicine, and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; Institute for Chemical Biology & Drug Discovery, Department of Chemistry, Stony Brook University, St...
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Coronary atherosclerosis is a progressive disease that involves vascular inflammation, development of cholesterol burdened atheroma, mechanisms of injury and repair, and subsequent calcification (1). Coronary artery calcification (CAC) detected with cardiac computed tomography has been shown to correlate well with overall plaque burden and is an independent predictor of cardiovascular events (2...
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Calcific aortic valve disease (CAVD) is the most common valvular disease in the developed world. The disease prevalence is projected to reach 4.5 billion worldwide in 2030, underscoring its significance as a worldwide public health burden. Valve replacement is the only established therapy, but despite recent advances, both surgical and transcatheter approaches still have substantial morbidity a...
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ژورنال
عنوان ژورنال: ACS Infectious Diseases
سال: 2020
ISSN: 2373-8227,2373-8227
DOI: 10.1021/acsinfecdis.9b00473